Three-dimensional, time-domain, wave-body interactions are studied in this paper for cases with and without forward speed. In the present approach, an exact body boundary condition and linearized free surface boundary conditions are used. By distributing desingularized sources above the calm water surface and using constant-strength flat panels on the exact wetted body surface, the boundary integral equations are numerically solved at each time step. Once the fluid velocities on the free surface are computed, the free surface elevation and potential are updated by integrating the free surface boundary conditions. After each time step, the body surface and free surface are regrided due to the instantaneous wetted body geometry. The desingularized method applied on the free surface produces nonsingular kernels in the integral equations by moving the fundamental singularities a small distance outside of the fluid domain. Constant-strength flat panels are used for bodies with any arbitrary shape. Extensive results are presented to validate the efficiency of the present method. These results include the added mass and damping computations for a hemisphere. The calm water wave resistance for a submerged spheroid and a Wigley hull are also presented. All the computations with forward speed are started from rest and proceeded until a steady state is reached. Finally, the time-domain forced motion results for a modified Wigley hull with forward speed are shown and compared to the experiments for both linear computations and body-exact computations.