This paper presents the analysis and design of single-point power-mooring cables applied to wave energy converters (WECs). A mooring cable design process is suggested, and effects of cable cross-sectional layout, material selection, and conductor design on cable properties are investigated. The study focuses on cable design and structural material for a long service life. Six designs and four structural materials were studied for a total of 18 different configurations. The materials used for the study included Vectran HS, Kevlar 49, carbon fibers in a vinyl ester matrix, and MP35N alloy. Cable design had minimal impact on cable properties. Material used and component helical angle exhibited significant impact on cable mechanical properties. Synthetic fiber designs exhibited more desirable mechanical properties and fatigue performance than both carbon fibers in a vinyl ester matrix and MP35N alloy. Wave device heave and cable tension were not affected by cable material.