The local buckling response and post-buckling mechanical performance of high strength linepipe subject to combined loading state was evaluated using the finite element (FE) simulator abaqus/standard v6.12. The constitutive model parameters were established through laboratory tests and the numerical modeling procedures were verified with large-scale experiments investigating the local buckling response of high strength linepipe. The numerical predictions demonstrated a high level of consistency and correspondence with the measured experimental behavior with respect to the peak moment, strain capacity, deformation mechanism, and local buckling response well into the postyield range. A parametric study on the local buckling response of high strength plain and girth weld pipelines was conducted. The loading conditions included internal pressure and end rotation. The pipe mechanical response parameters examined included moment–curvature, ovalization, local strain, and modal response. The magnitude and distribution of the characteristic geometric imperfections and the end constraint, associated with the boundary conditions and pipe length, had a significant influence on the predicted local buckling response. The importance of material parameters on the local buckling response, including the yield strength (YS), yield strength to tensile strength ratio (Y/T), and anisotropy, was also established through the numerical parameter study. For girth weld linepipe, the study demonstrated the importance of the local high/low misalignment, associated with the circumferential girth weld, on the local buckling response.