Infants spend most of the day sleeping anywhere. In the past, most parents put their infants to sleep in the prone position, but recently they put their infants to sleep in the prone position because of an issue of sudden infant death syndrome. When infants sleep in a supine position for a long time, occipital bone deformation is occurred because of pressure at the occipital region. To prevent minimize the pressure on the infant’s head and body, through the finite element simulation using the infant model, a baby cushion for the stroller was designed using the central composite design (CCD) method. The maximum contact pressure between the designed cushion and the infant model was 22.8 mmHg and this value is about 50 % lower than the pressure that occurred between the infant model and the general cushion. It can be helpful to reduce the possibility of a baby’s head deformation and other body disorders.