In this study, Reynolds-averaged Navier-Stokes simulation (RANS) of the uniform blowing and suction (UB/US) control on a Clark-Y airfoil was performed aiming at improving an airfoil performance by friction drag reduction. First, the control effect when only the uniform blowing control or uniform suction control is applied on the airfoil surface was investigated by changing the control locations. The blowing or suction velocity was 0.14% of the free-stream velocity and the blowing/suction area was set at four different locations from the leading edge to the trailing edge on both the upper and lower surfaces. The Reynolds number based on the chord length is 1.5 × 106. The angle of attack is set to 0°. It was found that friction drag is decreased/increased by single UB/US control. It was also found that the lift-to-drag ratio improved with UB on the lower surface or US on the upper surface, and decreased with UB on the upper surface or US on the lower surface. In the combined control of UB and US, the blowing and suction velocity was 0.14% or 0.26% of the free-stream velocity and the locations of blowing/suction and flow conditions were the same as those in the cases with either UB or US. It seemed that the lift-to-drag ratio was improved by the combined control of UB on the lower surface and US on the upper surface. In particular, the lift-to-drag ratio was most improved by US on the lower rear surface and UB on the upper rear surface.