In this study, the dispersion and deposition of particles in the respiratory system attached to a mannequin lying down inside a room were investigated numerically. The respiratory system model was prepared by processing the CT scan images of a volunteer and was attached to a mannequin lying in the middle of a room. The flow field around the mannequin and effects of the thermal plume on the particle aspiration by the mannequin model was simulated using the Ansys-Fluent software. The aspiration efficiency of spherical particles in the airway was studied with the Lagrangian particle trajectory analysis, including the turbulence dispersion effects. For validation of numerical simulations, the aspiration efficiency of the particles obtained from the numerical solution was compared with the case of a standing mannequin. The results are presented for two different modes with upward and downward thermal plumes. For the first mode, due to the strong effect of the thermal plume in the upward direction, the aspiration efficiency of midrange particles increases. However, the aspiration efficiency of large micro-particles decreases for the first mode. For the second mode, with the downward thermal plume, the aspiration efficiency of small micro-particles increases significantly.