This paper provides an assessment of three different machine learning techniques for accurately reproducing a distributed temperature prediction of a high-pressure turbine airfoil. A three-dimensional Finite Element Analysis thermal model of a cooled turbine airfoil was solved repeatedly (200 instances) for various operating point settings of the corresponding gas turbine engine. The response surface created by the repeated solutions was fed into three machine learning algorithms and surrogate model representations of the FEA model’s response were generated. The machine learning algorithms investigated were a Gaussian Process, a Boosted Decision Tree, and an Artificial Neural Network. Additionally, a simple Linear Regression surrogate model was created for comparative purposes. The Artificial Neural Network model proved to be the most successful at reproducing the FEA model over the range of operating points. The mean and standard deviation differences between the FEA and the Neural Network models were 15% and 14% of a desired accuracy threshold, respectively. The Digital Thread for Design (DT4D) was used to expedite all model execution and machine learning training. A description of DT4D is also provided.