In the present paper the influence of geometrical deviations, related to the manufacturing process or to a different hole positioning over the vane surface, and of coolant Reynolds number on flat plate film cooling through shaped holes are experimentally investigated. Hole geometrical parameters, such as the length of the cylindrical section, hole injection angle, lateral and forward expansion angles were varied and tested for blowing ratio M values between 1.0 and 2.0, also changing the coolant Reynolds number. The dual-luminophore Pressure Sensitive Paint (PSP) technique was used for measuring the adiabatic film cooling effectiveness distribution. Compared with the standard geometry, the V-shaped hole was shown to produce a better thermal protection, especially in the near hole region. Effectiveness is strongly affected by relatively small changes in the hole geometry, like the length of the cylindrical section and the forward expansion angle. A critical coolant Reynolds number was also identified, whose value changes depending on the hole geometry.