Tip leakage flow in high speed turbine induce significant thermal loads and give rise to intense thermal stresses on blade tip, while increasing inlet pressure tends to accelerate leakage velocity beyond transonic regime. The present research quantifies heat transfer and film cooling effect on a squealer tip with three film cooling layouts, three coolant mass flow rates and a relative casing movement. The results indicate that area-averaged HTC of PS layout is higher than that of CAM layout by 6.9% and that of SS layout by 5.7% when coolant flow rate equals to 0.6% mainstream flow rate. By comparison, it is clearly observed that area of the high heat transfer coefficient regions are significantly enlarged when the flow rate of coolant is increased. With relative casing movement, a significant high HTC stripe parallel to pressure side rim is formed. In case of the PS layout, heat transfer coefficient is reduced by 7.3% with casing movement. While in case of CAM layout and SS layout, heat transfer coefficient increased by 4.8% and 2.3% with casing movement, respectively. Detailed flow patterns with three film cooling layouts are also illustrated.