Rapid Prototyping (RP) technology has found applications in medicine. Model produced using rapid prototyping technique can enhance interpretation, visualization and physical evaluation, and is useful to pre-surgical operation. This paper presents an integrated reverse engineering system for biomedical application. The configuration of this integrated system consists of hardware and software layouts. The components within the hardware layout are completed except the fiber optic link. The components of the software layout are completed. The reverse engineering system using rapid prototyping technique is applied in the case studies of nose prosthesis and ear prosthesis.