Hydrostatic pressure (HP) regulates diverse cell behaviors including differentiation, migration, apoptosis, and proliferation. Abnormal HP is associated with pathologies including glaucoma and hypertensive fibrotic remodeling. In this review, recent advances in quantifying and predicting how cells respond to HP across several tissue systems are presented, including tissues of the brain, eye, vasculature and bladder, as well as articular cartilage. Finally, some promising directions on the study of cell behaviors regulated by HP are proposed.
Issue Section:
Review Article
References
1.
Chang
, L.
, Azzolin
, L.
, Di Biagio
, D.
, Zanconato
, F.
, Battilana
, G.
, Lucon Xiccato
, R.
, Aragona
, M.
, Giulitti
, S.
, Panciera
, T.
, Gandin
, A.
, Sigismondo
, G.
, Krijgsveld
, J.
, Fassan
, M.
, Brusatin
, G.
, Cordenonsi
, M.
, and Piccolo
, S.
, 2018
, “The SWI/SNF Complex is a Mechanoregulated Inhibitor of YAP and TAZ
,” Nature
, 563
(7730
), pp. 265
–269
.2.
Vining
, K. H.
, and Mooney
, D. J.
, 2017
, “Mechanical Forces Direct Stem Cell Behaviour in Development and Regeneration
,” Nat. Rev. Mol. Cell Biol.
, 18
, pp. 728
–742
.3.
Huang
, G.
, Xu
, F.
, Genin
, G. M.
, and Lu
, T. J.
, 2019
, “Mechanical Microenvironments of Living Cells: A Critical Frontier in Mechanobiology
,” Acta Mechanica Sinica
, 35
(2
), pp. 265
–269
.4.
Chen
, J.
, and Wang
, N.
, 2019
, “Tissue Cell Differentiation and Multicellular Evolution Via Cytoskeletal Stiffening in Mechanically Stressed Microenvironments
,” Acta Mechanica Sinica
, 35
(2
), pp. 270
–274
.5.
Xia
, Y.
, Pfeifer
, C. R.
, and Discher
, D. E.
, 2019
, “Nuclear Mechanics During and After Constricted Migration
,” Acta Mechanica Sinica
, 35
(2
), pp. 299
–308
.6.
Wolfe
, R. P.
, and Ahsan
, T.
, 2013
, “Shear Stress During Early Embryonic Stem Cell Differentiation Promotes Hematopoietic and Endothelial Phenotypes
,” Biotechnol. Bioeng.
, 110
(4
), pp. 1231
–1242
.7.
Wolfe
, R. P.
, Leleux
, J.
, Nerem
, R. M.
, and Ahsan
, T.
, 2012
, “Effects of Shear Stress on Germ Lineage Specification of Embryonic Stem Cells
,” Integr. Biol. UK
, 4
(10
), pp. 1263
–1273
.8.
Messina
, S. L.
, 2015
, “Effects of Oscillatory Shear Stress on Early Differentiation and Mechanotransduction
,” ProQuest Dissertations Publishing
, Ann Arbor, MI.
9.
Hsu
, H. J.
, Lee
, C. F.
, Locke
, A.
, Vanderzyl
, S. Q.
, and Kaunas
, R.
, 2010
, “Stretch-Induced Stress Fiber Remodeling and the Activations of JNK and ERK Depend on Mechanical Strain Rate, but Not FAK
,” PLoS One
, 5
(8
), p. e12470
.10.
Yang
, M.
, Xiao
, L. W.
, Liao
, E. Y.
, Wang
, Q. J.
, Wang
, B. B.
, and Lei
, J. X.
, 2014
, “The Role of Integrin-β/FAK in Cyclic Mechanical Stimulation in MG-63 Cells
,” Int. J. Clin. Exp. Pathol.
, 7
(11
), pp. 7451
–7459
.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270589/pdf/ijcep0007-7451.pdf11.
Wu
, Y.
, van der Schaft
, D. W. J.
, Baaijens
, F. P.
, and Oomens
, C. W. J.
, 2016
, “Cell Death Induced by Mechanical Compression on Engineered Muscle Results From a Gradual Physiological Mechanism
,” J. Biomech.
, 49
(7
), pp. 1071
–1077
.12.
Stewart
, M. P.
, Helenius
, J.
, Toyoda
, Y.
, Ramanathan
, S. P.
, Muller
, D. J.
, and Hyman
, A. A.
, 2011
, “Hydrostatic Pressure and the Actomyosin Cortex Drive Mitotic Cell Rounding
,” Nature
, 469
(7329
), pp. 226
–230
.13.
Stewart
, M. P.
, Mueller
, D. J.
, Helenius
, J.
, and Hyman
, A. A.
, 2010
, “Opposing Activities of Hydrostatic Pressure and Actomyosin Contraction Drive Mitotic Cell Rounding
,” Biophys. J.
, 98
(3
), p. 367a
.14.
Zonia
, L.
, and Munnik
, T.
, 2007
, “Life Under Pressure: Hydrostatic Pressure in Cell Growth and Function
,” Trends Plant Sci.
, 12
(3
), pp. 90
–97
.15.
Steward
, A. J.
, Thorpe
, S. D.
, Vinardell
, T.
, Buckley
, C. T.
, Wagner
, D. R.
, and Kelly
, D. J.
, 2012
, “Cell–Matrix Interactions Regulate Mesenchymal Stem Cell Response to Hydrostatic Pressure
,” Acta Biomater.
, 8
(6
), pp. 2153
–2159
.16.
Wu
, T.
, Chen
, L.
, Wei
, T.
, Wang
, Y.
, Xu
, F.
, and Wang
, K.
, 2012
, “Effect of Cyclic Hydrodynamic Pressure-Induced Proliferation of Human Bladder Smooth Muscle Through Ras-Related C3 Botulinum Toxin Substrate 1, Mitogen-Activated Protein Kinase Kinase 1/2 and Extracellular Regulated Protein Kinases 1/2
,” Int. J. Urol.
, 19
(9
), pp. 867
–874
.17.
Ju
, W.-K.
, Kim
, K.-Y.
, Lindsey
, J. D.
, Angert
, M.
, Patel
, A.
, Scott
, R. T.
, Liu
, Q.
, Crowston
, J. G.
, Ellisman
, M. H.
, and Perkins
, G. A.
, 2009
, “Elevated Hydrostatic Pressure Triggers Release of OPA1 and Cytochrome C, and Induces Apoptotic Cell Death in Differentiated RGC-5 Cells
,” Mol. Vis.
, 15
, pp. 120
–134
.18.
Acevedo
, A. D.
, Bowser
, S. S.
, Gerritsen
, M. E.
, and Bizios
, R.
, 1993
, “Morphological and Proliferative Responses of Endothelial Cells to Hydrostatic Pressure: Role of Fibroblast Growth Factor
,” J. Cell. Physiol.
, 157
(3
), pp. 603
–614
.19.
Xu
, T.
, Xu
, G.
, Gu
, Z.
, and Wu
, H.
, 2017
, “Role of Endoplasmic Reticulum Stress Pathway in Hydrostatic Pressure-Induced Apoptosis in Rat Mandibular Condylar Chondrocytes
,” Mol. Cell. Biochem.
, 429
(1–2
), pp. 22
–31
.20.
Markiewicz
, L.
, Pytel
, D.
, Mucha
, B.
, Szymanek
, K.
, Szaflik
, J.
, Szaflik
, J. P.
, and Majsterek
, I.
, 2015
, “Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients
,” Biomed. Res. Int.
, 2015
, p. 812503
.21.
Brockhaus
, K.
, Melkonyan
, H.
, Prokosch
, V.
, and Thanos
, S.
, 2017
, “Elevated Intraocular Pressure Induces Cellular Responses in the Retinal Capillaries
,” Klinische Monatsblätter Für Augenheilkunde
, 234
(10
), pp. 1266
–1275
.22.
Sampathkumar
, S.
, Schieber
, A. T.
, and Toris
, C. B.
, 2016
, “A Schlemm's Canal Scaffold for the Treatment of Elevated IOP
,” Expert Rev. Ophthalmol.
, 11
(4
), pp. 259
–266
.23.
Nusbaum
, D. M.
, Wu
, S. M.
, and Frankfort
, B. J.
, 2015
, “Elevated Intracranial Pressure Causes Optic Nerve and Retinal Ganglion Cell Degeneration in Mice
,” Exp. Eye Res.
, 136
, p. 38
.24.
Kershen
, R. T.
, Azadzoi
, K. M.
, and Siroky
, M. B.
, 2002
, “Blood Flow, Pressure and Compliance in the Male Human Bladder
,” J. Urol.
, 168
(1
), pp. 121
–125
.25.
Stover
, J.
, and Nagatomi
, J.
, 2007
, “Cyclic Pressure Stimulates DNA Synthesis Through the PI3K/Akt Signaling Pathway in Rat Bladder Smooth Muscle Cells
,” Ann. Biomed. Eng.
, 35
(9
), pp. 1585
–1594
.26.
Thomopoulos
, S.
, Das
, R.
, Birman
, V.
, Smith
, L.
, Ku
, K.
, Elson
, E. L.
, Pryse
, K. M.
, Marquez
, J. P.
, and Genin
, G. M.
, 2011
, “Fibrocartilage Tissue Engineering: The Role of the Stress Environment on Cell Morphology and Matrix Expression
,” Tissue Eng. Part A
, 17
(7–8
), pp. 1039
–1053
.27.
Elder
, B. D.
, and Athanasiou
, K. A.
, 2009
, “Hydrostatic Pressure in Articular Cartilage Tissue Engineering: From Chondrocytes to Tissue Regeneration
,” Tissue Eng. Part B: Rev.
, 15
(1
), pp. 43
–53
.28.
Mauck
, R. L.
, Nicoll
, S. B.
, Seyhan
, S. L.
, Ateshian
, G. A.
, and Hung
, C. T.
, 2003
, “Synergistic Action of Growth Factors and Dynamic Loading for Articular Cartilage Tissue Engineering
,” Tissue Eng. Part A
, 9
(4
), p. 597
.29.
Huang
, G.
, Li
, F.
, Zhao
, X.
, Ma
, Y.
, Li
, Y.
, Lin
, M.
, Jin
, G.
, Lu
, T. J.
, Genin
, G. M.
, and Xu
, F.
, 2017
, “Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
,” Chem. Rev.
, 117
(20
), pp. 12764
–12850
.30.
Hall
, A. C.
, Urban
, J. P.
, and Gehl
, K. A.
, 1991
, “The Effects of Hydrostatic Pressure on Matrix Synthesis in Articular Cartilage
,” J. Orthop. Res.
, 9
(1
), pp. 1
–10
.31.
Smith
, L.
, Xia
, Y.
, Galatz
, L. M.
, Genin
, G. M.
, and Thomopoulos
, S.
, 2012
, “Tissue-Engineering Strategies for the Tendon/Ligament-to-Bone Insertion
,” Connect. Tissue Res.
, 53
(2
), pp. 95
–105
.32.
Thomopoulos
, S.
, Birman
, V.
, and Genin
, G. M.
, 2013
, Structural Interfaces and Attachments in Biology, Springer, Berlin.33.
Ohashi
, T.
, Sugaya
, Y.
, Sakamoto
, N.
, and Sato
, M.
, 2007
, “Hydrostatic Pressure Influences Morphology and Expression of VE-Cadherin of Vascular Endothelial Cells
,” J. Biomech.
, 40
(11
), pp. 2399
–2405
.34.
Sun
, Y.
, Luo
, D.
, Zhu
, Y.
, and Wang
, K.
, 2017
, “MicroRNA 4323 Induces Human Bladder Smooth Muscle Cell Proliferation Under Cyclic Hydrodynamic Pressure by Activation of Erk1/2 Signaling Pathway
,” Exp. Biol. Med.
, 242
(2
), pp. 169
–176
.35.
Sun
, Y.
, Luo
, D. Y.
, Zhu
, Y. C.
, Zhou
, L.
, Yang
, T. X.
, Tang
, C.
, Shen
, H.
, and Wang
, K. J.
, 2016
, “MiR 3180-5p Promotes Proliferation in Human Bladder Smooth Muscle Cell by Targeting PODN Under Hydrodynamic Pressure
,” Sci. Rep.
, 6
, p. 33042
.36.
Sappington
, R. M.
, Sidorova
, T.
, Long
, D. J.
, and Calkins
, D. J.
, 2009
, “TRPV1: Contribution to Retinal Ganglion Cell Apoptosis and Increased Intracellular Ca2+ With Exposure to Hydrostatic Pressure
,” Invest. Ophthalmol. Vis. Sci.
, 50
(2
), pp. 717
–728
.37.
Karamesinis
, K.
, Spyropoulou
, A.
, Dalagiorgou
, G.
, Katsianou
, M. A.
, Nokhbehsaim
, M.
, Memmert
, S.
, Deschner
, J.
, Vastardis
, H.
, and Piperi
, C.
, 2017
, “Continuous Hydrostatic Pressure Induces Differentiation Phenomena in Chondrocytes Mediated by Changes in Polycystins, SOX9, and RUNX2
,” J. Orofacial Orthop.
, 78
(1
), pp. 1
–11
.38.
Kao
, Y. C.
, Jheng
, J. R.
, Pan
, H. J.
, Liao
, W. Y.
, Lee
, C. H.
, and Kuo
, P. L.
, 2017
, “Elevated Hydrostatic Pressure Enhances the Motility and Enlarges the Size of the Lung Cancer Cells Through Aquaporin Upregulation Mediated by Caveolin-1 and ERK1/2 Signaling
,” Oncogene
, 36
(6
), pp. 863
–874
.39.
Hui
, T. H.
, Zhou
, Z. L.
, Qian
, J.
, Lin
, Y.
, Ngan
, A. H.
, and Gao
, H.
, 2014
, “Volumetric Deformation of Live Cells Induced by Pressure-Activated Cross-Membrane Ion Transport
,” Phys. Rev. Lett.
, 113
(11
), p. 118101
.40.
Champaigne
, K. D.
, and Nagatomi
, J.
, 2012
, The Role of Ion Channels in Cellular Mechanotransduction of Hydrostatic Pressure
, Springer
, Cham, The Netherlands
.41.
Steiner
, L. A.
, and Andrews
, P. J.
, 2006
, “Monitoring the Injured Brain: ICP and CBF
,” Brit. J. Anaesth.
, 97
(1
), pp. 26
–38
.42.
Graham
, D. I.
, Adams
, J. H.
, and Doyle
, D.
, 1978
, “Ischemic Brain-Damage in Fatal Non-Missile Head-Injuries
,” J. Neurol. Sci.
, 39
(2–3
), pp. 213
–234
.43.
Guo
, T.
, Ren
, P.
, Li
, X.
, Luo
, T.
, Gong
, Y.
, Hao
, S.
, and Wang
, B.
, 2018
, “Neural Injuries Induced by Hydrostatic Pressure Associated With Mass Effect After Intracerebral Hemorrhage
,” Sci. Rep.
, 8
(1
), p. 9195
.44.
Yoshino
, D.
, Sato
, K.
, and Sato
, M.
, 2015
, “Endothelial Cell Response Under Hydrostatic Pressure Condition Mimicking Pressure Therapy
,” Cell Mol. Bioeng.
, 8
(2
), pp. 296
–303
.45.
Pascarelli
, N. A.
, Collodel
, G.
, Moretti
, E.
, Cheleschi
, S.
, and Fioravanti
, A.
, 2015
, “Changes in Ultrastructure and Cytoskeletal Aspects of Human Normal and Osteoarthritic Chondrocytes Exposed to Interleukin-1β and Cyclical Hydrostatic Pressure
,” Int. J. Mol. Sci.
, 16
(11
), pp. 26019
–26034
.46.
Aptel
, F.
, Weinreb
, R. N.
, Chiquet
, C.
, and Mansouri
, K.
, 2016
, “24-H Monitoring Devices and Nyctohemeral Rhythms of Intraocular Pressure
,” Prog. Retinal Eye Res.
, 55
, pp. 108
–148
.47.
Mantravadi
, A. V.
, and Vadhar
, N.
, 2015
, “Glaucoma
,” Primary Care
, 42
(3
), pp. 437
–449
.48.
Bendayan
, M.
, Sandborn
, E.
, Rasio
, E.
, Inoue
, S.
, Michel
, R. P.
, Hogg
, J. C.
, Hammersen
, F.
, Osgood
, C. P.
, Dujovny
, M.
, and Barrionuevo
, P. J.
, 1976
, Blood Vessel Structure
, Springer
, Berlin
.49.
Ogedegbe
, G.
, and Pickering
, T.
, 2010
, “Principles and Techniques of Blood Pressure Measurement
,” Cardiol. Clin.
, 28
(4
), pp. 571
–586
.50.
Hiitola
, P.
, Enlund
, H.
, Kettunen
, R.
, Sulkava
, R.
, and Hartikainen
, S.
, 2009
, “Postural Changes in Blood Pressure and the Prevalence of Orthostatic Hypotension Among Home-Dwelling Elderly Aged 75 Years or Older
,” J. Hum. Hypertens.
, 23
, pp. 33
–39
.51.
Xie
, X.
, Atkins
, E.
, Lv
, J.
, Bennett
, A.
, Neal
, B.
, Ninomiya
, T.
, Woodward
, M.
, MacMahon
, S.
, Turnbull
, F.
, Hillis
, G. S.
, Chalmers
, J.
, Mant
, J.
, Salam
, A.
, Rahimi
, K.
, Perkovic
, V.
, and Rodgers
, A.
, 2016
, “Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: Updated Systematic Review and Meta-Analysis
,” Lancet
, 387
(10017
), pp. 435
–443
.52.
Mcguire
, E. J.
, Woodside
, J. R.
, Borden
, T. A.
, and Weiss
, R. M.
, 1981
, “Prognostic Value of Urodynamic Testing in Myelodysplastic Patients
,” J. Urol.
, 126
(2
), pp. 1049
–1053
.53.
Naqvi
, S.
, Potluri
, P.
, Mandal
, P.
, and Lewis
, P.
, 2018
, “Effect of Different Cuff Types on Blood Pressure Measurement: Variation in BP Values for Different Cuff Types
,” J. Ind. Text.
, 47
(7
), pp. 1478
–1495
.54.
Zheng
, Y. L.
, Yan
, B. P.
, Zhang
, Y. T.
, and Poon
, C. C. Y.
, 2014
, “An Armband Wearable Device for Overnight and Cuff-Less Blood Pressure Measurement
,” IEEE Trans. Biomed. Eng.
, 61
(7
), pp. 2179
–2186
.55.
Bakx
, C.
, Oerlemans
, G.
, Van
, D. H. H.
, Van
, W. C.
, and Thien
, T.
, 1997
, “The Influence of Cuff Size on Blood Pressure Measurement
,” J. Hum. Hypertens.
, 11
(7
), pp. 439
–445
.56.
Giannoglou
, G. D.
, Chatzizisis
, Y. S.
, Zamboulis
, C.
, Parcharidis
, G. E.
, Mikhailidis
, D. P.
, and Louridas
, G. E.
, 2008
, “Elevated Heart Rate and Atherosclerosis: An Overview of the Pathogenetic Mechanisms
,” Int. J. Cardiol.
, 126
(3
), pp. 302
–312
.57.
Finley
, J. P.
, and Nugent
, S. T.
, 1995
, “Heart Rate Variability in Infants, Children and Young Adults
,” J. Autonom. Nerv. Syst.
, 51
(2
), pp. 103
–108
.58.
Chen
, L.
, Wei
, T. Q.
, Wang
, Y.
, Zhang
, J.
, Li
, H.
, and Wang
, K. J.
, 2012
, “Simulated Bladder Pressure Stimulates Human Bladder Smooth Muscle Cell Proliferation Via the PI3K/SGK1 Signaling Pathway
,” J. Urol.
, 188
(2
), pp. 661
–667
.59.
Rathore
, D.
, Shree
, S.
, Mukherjee
, A.
, and Jameel
, S.
, 2014
, “Wireless Measurement of Intraocular Pressure
,” Int. J. Adv. Eng. Technol.
, 7
(4
), pp. 1342
–1346
, http://www.e-ijaet.org/media/26I22-IJAET0722610_v7_iss4_1342-1346.pdf60.
Reddy
, S. C.
, and Alias
, R.
, 2014
, “Tono-Pen Measurement of Intraocular Pressure Under Topical Anaesthesia in Full Term Normal Newborns
,” Int. J. Ophthalmol.
, 7
(1
), pp. 92
–94
.61.
Li
, R.
, and Liu
, J. H. K.
, 2008
, “Telemetric Monitoring of 24 h Intraocular Pressure in Conscious and Freely Moving C57BL/6J and CBA/CaJ Mice
,” Mol. Vis.
, 14
(87–89
), pp. 745
–749
.62.
Nickla
, D. L.
, Wildsoet
, C.
, and Wallman
, J.
, 1998
, “The Circadian Rhythm in Intraocular Pressure and Its Relation to Diurnal Ocular Growth Changes in Chicks
,” Exp. Eye Res.
, 66
(2
), pp. 183
–193
.63.
Correia
, C.
, Pereira
, A. L.
, Duarte
, A. R.
, Frias
, A. M.
, Pedro
, A. J.
, Oliveira
, J. T.
, Sousa
, R. A.
, and Reis
, R. L.
, 2012
, “Dynamic Culturing of Cartilage Tissue: The Significance of Hydrostatic Pressure
,” Tissue Eng. Part A
, 18
(19–20
), pp. 1979
–1991
.64.
Finger
, A. R.
, Sargent
, C. Y.
, Dulaney
, K. O.
, Bernacki
, S. H.
, and Loboa
, E. G.
, 2007
, “Differential Effects on Messenger Ribonucleic Acid Expression by Bone Marrow-Derived Human Mesenchymal Stem Cells Seeded in Agarose Constructs Due to Ramped and Steady Applications of Cyclic Hydrostatic Pressure
,” Tissue Eng.
, 13
(6
), pp. 1151
–1158
.65.
Raboel
, P. H.
, Bartek
, J.
, Andresen
, M.
, Bellander
, B. M.
, and Romner
, B.
, 2012
, “Intracranial Pressure Monitoring: Invasive Versus Non-Invasive Methods—A Review
,” Crit. Care Res. Practice
, 2012
(12
), p. 950393
.66.
Bruce
, D. A.
, Langfitt
, T. W.
, Miller
, J. D.
, Schutz
, H.
, Vapalahti
, M. P.
, Stanek
, A.
, and Goldberg
, H. I.
, 1973
, “Regional Cerebral Blood Flow, Intracranial Pressure, and Brain Metabolism in Comatose Patients
,” J. Neurosurg.
, 38
(2
), pp. 131
–144
.67.
Wilson
, T. A.
, 2016
, Lung Mechanics
, Springer
, Berlin
.68.
Washko
, G. R.
, O'Donnell
, C. R.
, and Loring
, S. H.
, 2006
, “Volume-Related and Volume-Independent Effects of Posture on Esophageal and Transpulmonary Pressures in Healthy Subjects
,” J. Appl. Physiol.
, 100
(3
), pp. 753
–758
.69.
Blumgart
, H. L.
, and Yens
, O. C.
, 1927
, “Studies on the Velocity of Blood Flow—I: The Method Utilized
,” J. Clin. Invest.
, 4
(1
), pp. 1
–13
.70.
Guilak
, F.
, and Mow
, V. C.
, 2000
, “The Mechanical Environment of the Chondrocyte: A Biphasic Finite Element Model of Cell–Matrix Interactions in Articular Cartilage
,” J. Biomech.
, 33
(12
), pp. 1663
–1673
.71.
Jones
, B.
, Hung
, C. T.
, and Ateshian
, G.
, 2016
, “Biphasic Analysis of Cartilage Stresses in the Patellofemoral Joint
,” J. Knee Surg.
, 29
(2
), pp. 92
–98
.72.
Smith
, R. L.
, Lin
, J.
, Trindade
, M. C.
, Shida
, J.
, Kajiyama
, G.
, Vu
, T.
, Hoffman
, A. R.
, van der Meulen
, M. C.
, Goodman
, S. B.
, Schurman
, D. J.
, and Carter
, D. R.
, 2000
, “Time-Dependent Effects of Intermittent Hydrostatic Pressure on Articular Chondrocyte Type II Collagen and Aggrecan mRNA Expression
,” J. Rehabil. Res. Dev.
, 37
(2
), pp. 153
–161
.73.
Andriacchi
, T. P.
, 2002
, “Dynamic Function and Imaging in the Analysis of Osteoarthritis at the Knee
,” The Many Faces of Osteoarthritis, Springer, Birkhäuser, Basel, pp. 443
–452
.74.
Rushfeldt
, P. D.
, Mann
, R. W.
, and Harris
, W. H.
, 1981
, “Improved Techniques for Measuring In Vivo the Geometry and Pressure Distribution in the Human Acetabulum—II: Instrumented Endoprosthesis Measurement of Articular Surface Pressure Distribution
,” J. Biomech.
, 14
(5
), pp. 315
–323
.75.
Yu
, J.
, Zhong
, Y.
, Cheng
, Y.
, Shen
, X.
, Wang
, J.
, and Wei
, Y.
, 2011
, “Effect of High Hydrostatic Pressure on the Expression of Glutamine Synthetase in Rat Retinal Muller Cells Cultured In Vivo
,” Exp. Ther. Med.
, 2
(3
), pp. 513
–516
.76.
Liu
, C.
, Zhao
, Y.
, Cheung
, W.-Y.
, Gandhi
, R.
, Wang
, L.
, and You
, L.
, 2010
, “Effects of Cyclic Hydraulic Pressure on Osteocytes
,” Bone
, 46
(5
), pp. 1449
–1456
.77.
Haberstroh
, K. M.
, Kaefer
, M.
, Retik
, A. B.
, Freeman
, M. R.
, and Bizios
, R.
, 1999
, “The Effects of Sustained Hydrostatic Pressure on Select Bladder Smooth Muscle Cell Functions
,” J. Urol.
, 162
(6
), pp. 2114
–2118
.78.
Mandal
, A.
, Shahidullah
, M.
, and Delamere
, N. A.
, 2010
, “Hydrostatic Pressure–Induced Release of Stored Calcium in Cultured Rat Optic Nerve Head Astrocytes
,” Invest. Ophthalmol. Vis. Sci.
, 51
(6
), pp. 3129
–3138
.79.
Lei
, Y.
, Rajabi
, S.
, Pedrigi
, R. M.
, Overby
, D. R.
, Read
, A. T.
, and Ethier
, C. R.
, 2011
, “In Vitro Models for Glaucoma Research: Effects of Hydrostatic Pressure
,” Investigative ophthalmology & visual science
, 52
(9
), pp. 6329
–6339
.80.
Smith
, M. E.
, and Eskandari
, R.
, 2018
, “A Novel Technology to Model Pressure-Induced Cellular Injuries in the Brain
,” J. Neurosci. Meth.
, 293
, pp. 247
–253
.81.
Ju
, W.-K.
, Liu
, Q.
, Kim
, K.-Y.
, Crowston
, J. G.
, Lindsey
, J. D.
, Agarwal
, N.
, Ellisman
, M. H.
, Perkins
, G. A.
, and Weinreb
, R. N.
, 2007
, “Elevated Hydrostatic Pressure Triggers Mitochondrial Fission and Decreases Cellular ATP in Differentiated RGC-5 Cells
,” Invest. Ophthalmol. Vis. Sci.
, 48
(5
), pp. 2145
–2151
.82.
Wei
, T. Q.
, Luo
, D. Y.
, Chen
, L.
, Wu
, T.
, and Wang
, K. J.
, 2014
, “Cyclic Hydrodynamic Pressure Induced Proliferation of Bladder Smooth Muscle Cells Via Integrin Alpha5 and FAK
,” Physiol. Res.
, 63
(1
), pp. 127
–134
.https://www.ncbi.nlm.nih.gov/pubmed/2418234183.
Agar
, A.
, Li
, S.
, Agarwal
, N.
, Coroneo
, M. T.
, and Hill
, M. A.
, 2006
, “Retinal Ganglion Cell Line Apoptosis Induced by Hydrostatic Pressure
,” Brain Res.
, 1086
(1
), pp. 191
–200
.84.
Guo
, L.
, Moss
, S. E.
, Alexander
, R. A.
, Ali
, R. R.
, Fitzke
, F. W.
, and Cordeiro
, M. F.
, 2005
, “Retinal Ganglion Cell Apoptosis in Glaucoma is Related to Intraocular Pressure and IOP-Induced Effects on Extracellular Matrix
,” Investigative Opthalmol. Visual Sci.
, 46
(1
), pp. 175
–182
.85.
Sayyad
, Z.
, Sirohi
, K.
, Radha
, V.
, and Swarup
, G.
, 2017
, “661W is a Retinal Ganglion Precursor-Like Cell Line in Which Glaucoma-Associated Optineurin Mutants Induce Cell Death Selectively
,” Sci. Rep.
, 7
(1
), p. 16855
.86.
Krishnamoorthy
, R. R.
, Clark
, A. F.
, Daudt
, D.
, Vishwanatha
, J. K.
, and Yorio
, T.
, 2013
, “A Forensic Path to RGC-5 Cell Line Identification: Lessons Learned
,” Investigative Ophthal. Visual Sci.
, 54
(8
), pp. 5712
–5719
.87.
Osborne
, A.
, Aldarwesh
, A.
, Rhodes
, J. D.
, Broadway
, D. C.
, Everitt
, C.
, and Sanderson
, J.
, 2015
, “Hydrostatic pressure does not cause detectable changes in survival of human retinal ganglion cells
,” PloS one
, 10
(1
), p. e0115591
.88.
Sugaya
, Y.
, Sakamoto
, N.
, Ohashi
, T.
, and Sato
, M.
, 2003
, “Elongation and Random Orientation of Bovine Endothelial Cells in Response to Hydrostatic Pressure: Comparison With Response to Shear Stress
,” JSME Int. J. Ser. C Mech. Syst. Mach. Elem. Manuf.
, 46
(4
), pp. 1248
–1255
.89.
Schwartz
, E. A.
, Bizios
, R.
, Medow
, M. S.
, and Gerritsen
, M. E.
, 1999
, “Exposure of Human Vascular Endothelial Cells to Sustained Hydrostatic Pressure Stimulates Proliferation. Involvement of the AlphaV Integrins
,” Circ. Res.
, 84
(3
), pp. 315
–322
.90.
Tworkoski
, E.
, Glucksberg
, M. R.
, and Johnson
, M.
, 2018
, “The Effect of the Rate of Hydrostatic Pressure Depressurization on Cells in Culture
,” PloS one
, 13
(1
), p. e0189890
.91.
Suh
, J.-K.
, Baek
, G. H.
, Arøen
, A.
, Malin
, C. M.
, Niyibizi
, C.
, Evans
, C. H.
, and Westerhausen-Larson
, A.
, 1999
, “Intermittent Sub-Ambient Interstitial Hydrostatic Pressure as a Potential Mechanical Stimulator for Chondrocyte Metabolism
,” Osteoarthritis Cartilage
, 7
(1
), p. 71
.92.
Smith
, R. L.
, Rusk
, S. F.
, Ellison
, B. E.
, Wessells
, P.
, Tsuchiya
, K.
, Carter
, D. R.
, Caler
, W. E.
, Sandell
, L. J.
, and Schurman
, D. J.
, 1996
, “In Vitro Stimulation of Articular Chondrocyte mRNA and Extracellular Matrix Synthesis by Hydrostatic Pressure
,” J. Orthop. Res.
, 14
(1
), pp. 53
–60
.93.
Miyanishi
, K.
, Trindade
, M. C.
, Lindsey
, D. P.
, Beaupré
, G. S.
, Carter
, D. R.
, Goodman
, S. B.
, Schurman
, D. J.
, and Smith
, R. L.
, 2006
, “Effects of Hydrostatic Pressure and Transforming Growth Factor-Beta 3 on Adult Human Mesenchymal Stem Cell Chondrogenesis In Vitro
,” Tissue Eng.
, 12
(6
), pp. 1419
–1428
.94.
Nathan
, S. S.
, Di Resta
, R. G.
, Casas-Ganem
, J. E.
, Hoang
, B. H.
, Sowers
, R.
, Yang
, R.
, Huvos
, A. G.
, Gorlick
, R.
, and Healey
, J. H.
, 2005
, “Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma
,” Clin. Cancer Res.
, 11
(6
), p. 2389
.95.
Frey
, B.
, Janko
, C.
, Ebel
, N.
, Meister
, S.
, Schlücker
, E.
, Meyer-Pittroff
, R.
, Fietkau
, R.
, Herrmann
, M.
, and Gaipl
, U. S.
, 2008
, “Cells Under Pressure—Treatment of Eukaryotic Cells With High Hydrostatic Pressure, From Physiologic Aspects to Pressure Induced Cell Death
,” Curr. Med. Chem.
, 15
(23
), pp. 2329
–2336
.96.
Baldwin
, C.
, Potter
, M.
, Clayton
, E.
, Irvine
, L.
, and Dye
, J.
, 2009
, “Topical Negative Pressure Stimulates Endothelial Migration and Proliferation: A Suggested Mechanism for Improved Integration of Integra
,” Ann. Plast. Surg.
, 62
(1
), pp. 92
–96
.97.
Stroka
, K.
, Jiang
, H.
, Chen
, S. H.
, Tong
, Z.
, Wirtz
, D.
, Sun
, S.
, and Konstantopoulos
, K.
, 2014
, “Water Permeation Drives Tumor Cell Migration in Confined Microenvironments
,” Cell
, 157
(3
), pp. 611
–623
.98.
Jiang
, H.
, and Sun
, S.
, 2013
, “Cellular Pressure and Volume Regulation and Implications for Cell Mechanics
,” Biophys. J.
, 105
(3
), pp. 609
–619
.99.
van't Hoff
, J.
, 1901
, “Osmotic Pressure and Chemical Equilibrium
,” Nobel Prize Lecture, Sweden, accessed July 8, 2019, https://www.nobelprize.org/uploads/2018/06/hoff-lecture.pdf100.
Joanny
, J. F.
, and Prost
, J.
, 2009
, “Active Gels as a Description of the Actin-Myosin Cytoskeleton
,” HFSP J.
, 3
(2
), pp. 94
–104
.101.
Holzbaur
, E. L.
, and Goldman
, Y. E.
, 2010
, “Coordination of Molecular Motors: From In Vitro Assays to Intracellular Dynamics
,” Curr. Opin. Cell Biol.
, 22
(1
), pp. 4
–13
.102.
Cruz
, E. M. D. L.
, and Ostap
, E. M.
, 2004
, “Relating Biochemistry and Function in the Myosin Superfamily
,” Curr. Opin. Cell Biol.
, 16
(1
), pp. 61
–67
.103.
Elson
, E. L.
, and Genin
, G. M.
, 2013
, “The Role of Mechanics in Actin Stress Fiber Kinetics
,” Exp. Cell Res.
, 319
(16
), pp. 2490
–2500
.104.
Marquez
, J. P.
, Elson
, E. L.
, and Genin
, G. M.
, 2010
, “Whole Cell Mechanics of Contractile Fibroblasts: Relations Between Effective Cellular and Extracellular Matrix Moduli
,” Philos. Trans. R. Soc. A
, 368
(1912
), pp. 635
–654
.105.
Cao
, X.
, Moeendarbary
, E.
, Isermann
, P.
, Davidson
, P.
, Wang
, X.
, Chen
, M.
, Burkart
, A.
, Lammerding
, J.
, Kamm
, R.
, and Shenoy
, V.
, 2016
, “A Chemomechanical Model for Nuclear Morphology and Stresses During Cell Transendothelial Migration
,” Biophys. J.
, 111
(7
), pp. 1541
–1552
.106.
Mcgarry
, J. P.
, Fu
, J.
, Yang
, M. T.
, Chen
, C. S.
, Mcmeeking
, R. M.
, Evans
, A. G.
, and Deshpande
, V. S.
, 2009
, “Simulation of the Contractile Response of Cells on an Array of Micro-Posts
,” Philos. Trans. R. Soc. A
, 367
(1902
), pp. 3477
–3497
.107.
Tao
, J.
, Li
, Y.
, Vig
, D. K.
, and Sun
, S. X.
, 2017
, “Cell Mechanics: A Dialogue
,” Rep. Prog. Phys.
, 80
(3
), p. 036601
.108.
Jia
, X. T.
, and Sun
, S. X.
, 2015
, “Active Biochemical Regulation of Cell Volume and a Simple Model of Cell Tension Response
,” Biophys. J.
, 109
(8
), pp. 1541
–1550
.109.
Jean-Yves
, T.
, Ulrike
, S.
, Guillaume
, S.
, Julia
, R.
, Jean-François
, J.
, and Ewa
, P.
, 2009
, “Role of Cortical Tension in Bleb Growth
,” Proc. Natl. Acad. Sci. U. S. A.
, 106
(44
), pp. 18581
–18586
.110.
Guillaume
, C.
, and Ewa
, P.
, 2008
, “Blebs Lead the Way: How to Migrate Without Lamellipodia
,” Nat. Rev. Mol. Cell Biol.
, 9
(9
), pp. 730
–736
.111.
Jülicher
, F.
, Kruse
, K.
, Prost
, J.
, and Joanny
, J. F.
, 2007
, “Active Behavior of the Cytoskeleton
,” Phys. Rep.
, 449
(1
), pp. 3
–28
.112.
Matthews
, B. D.
, Overby
, D. R.
, Mannix
, R.
, and Ingber
, D. E.
, 2006
, “Cellular Adaptation to Mechanical Stress: Role of Integrins, Rho, Cytoskeletal Tension and Mechanosensitive Ion Channels
,” J. Cell Sci.
, 119
(3
), pp. 508
–518
.113.
Tianzhi
, L.
, Krithika
, M.
, Iglesias
, P. A.
, and Robinson
, D. N.
, 2013
, “Molecular Mechanisms of Cellular Mechanosensing
,” Nat. Mater.
, 12
(11
), pp. 1063
–1070
.114.
Rodrigo
, F. G.
, and Zallen
, J. A.
, 2009
, “Cell Mechanics and Feedback Regulation of Actomyosin Networks
,” Sci. Signal.
, 2
(101
), pp. 5306
–5313
. 115.
Nekouzadeh
, A.
, Pryse
, K. M.
, Elson
, E. L.
, and Genin
, G. M.
, 2008
, “Stretch-Activated Force Shedding, Force Recovery, and Cytoskeletal Remodeling in Contractile Fibroblasts
,” J. Biomech.
, 41
(14
), pp. 2964
–2971
.116.
Elson
, E. L.
, Fried
, E.
, Dolbow
, J. E.
, and Genin
, G. M.
, 2010
, “Phase Separation in Biological Membranes: Integration of Theory and Experiment
,” Annu. Rev. Biophys.
, 39
(1
), pp. 207
–226
.117.
Greenberg
, M. J.
, Arpağ
, G.
, Tüzel
, E.
, and Ostap
, E. M.
, 2016
, “A Perspective on the Role of Myosins as Mechanosensors
,” Biophys. J.
, 110
(12
), pp. 2568
–2576
.118.
Wagner
, B.
, Tharmann
, R.
, Haase
, I.
, Fischer
, M.
, and Bausch
, A. R.
, 2006
, “Cytoskeletal Polymer Networks: The Molecular Structure of Cross-Linkers Determines Macroscopic Properties
,” Proc. Natl. Acad. Sci. U. S. A.
, 103
(38
), pp. 13974
–13978
.119.
Yi
, X. R.
, Effler
, J. C.
, Melanie
, N.
, Tianzhi
, L.
, Firtel
, R. A.
, Iglesias
, P. A.
, Rock
, R. S.
, and Robinson
, D. N.
, 2009
, “Mechanosensing Through Cooperative Interactions Between Myosin II and the Actin Crosslinker Cortexillin I
,” Curr. Biol.
, 19
(17
), pp. 1421
–1428
.120.
Humphrey
, D.
, Duggan
, C.
, Saha
, D.
, Smith
, D.
, and Käs
, J.
, 2002
, “Active Fluidization of Polymer Networks Through Molecular Motors
,” Nature
, 416
(6879
), pp. 413
–416
.121.
Falk
, W.
, Stefan
, S.
, Bryan
, L.
, Revathi
, A.
, Maren
, R.
, Jochen
, G.
, and Josef
, K. S.
, 2005
, “Optical Rheology of Biological Cells
,” Phys. Rev. Lett.
, 94
(9
), p. 098103
.122.
Cornelis
, S.
, Pastore
, J. J.
, Mackintosh
, F. C.
, Lubensky
, T. C.
, and Janmey
, P. A.
, 2005
, “Nonlinear Elasticity in Biological Gels
,” Nature
, 435
(7039
), pp. 191
–194
.123.
Daisuke
, M.
, Catherine
, T.
, Schmidt
, C. F.
, and Mackintosh
, F. C.
, 2007
, “Nonequilibrium Mechanics of Active Cytoskeletal Networks
,” Science
, 315
(5810
), pp. 370
–373
.124.
Chen
, P.
, and Shenoy
, V. B.
, 2011
, “Strain Stiffening Induced by Molecular Motors in Active Crosslinked Biopolymer Networks
,” Soft Matter.
, 7
(2
), pp. 355
–358
.125.
Carlsson
, A. E.
, 2010
, “Actin Dynamics: From Nanoscale to Microscale
,” Annu. Rev. Biophys.
, 39
(39
), pp. 91
–110
.126.
Dasanayake
, N. L.
, and Carlsson
, A. E.
, 2012
, “General Mechanism of Actomyosin Contraction
,” Biophys. J.
, 102
(3
), p. 349a
.127.
Dasanayake
, N. L.
, Michalski
, P. J.
, and Carlsson
, A. E.
, 2011
, “General Mechanism of Actomyosin Contractility
,” Phys. Rev. Lett.
, 107
(11
), p. 118101
.128.
Naganathan
, S. R.
, Fürthauer
, S.
, Nishikawa
, M.
, Jülicher
, F.
, and Grill
, S. W.
, 2014
, “Active Torque Generation by the Actomyosin Cell Cortex Drives Left–Right Symmetry Breaking
,” eLife
, 3
, p. e04165
.129.
Mirjam
, M.
, Martin
, D.
, Bois
, J. S.
, Frank
, J.
, and Grill
, S. W.
, 2010
, “Anisotropies in Cortical Tension Reveal the Physical Basis of Polarizing Cortical Flows
,” Nature
, 467
, pp. 617
–621
.130.
Carlsson
, A.
, 2018
, “How Actin Polymerization Bends the Cell Membrane to Drive Endocytosis
,” Biophys. J.
, 114
(3
), p. 388a
.131.
He
, L.
, Tao
, J.
, Maity
, D.
, Si
, F.
, Wu
, Y.
, Wu
, T.
, Prasath
, V.
, Wirtz
, D.
, and Sun
, S. X.
, 2018
, “Role of Membrane-Tension Gated Ca2+ Flux in Cell Mechanosensation
,” J. Cell Sci.
, 131
(4
), p. jcs208470
.132.
Else Kay
, H.
, Niels Bjerre
, H.
, and Ian Henry
, L.
, 2014
, “Functions of Volume-Sensitive and Calcium-Activated Chloride Channels
,” IUBMB Life
, 66
(4
), pp. 257
–267
.133.
Sardini
, A.
, Amey
, J. S.
, Weylandt
, K. H.
, Nobles
, M.
, Valverde
, M. A.
, and Higgins
, C. F.
, 2003
, “Cell Volume Regulation and Swelling-Activated Chloride Channels
,” BBA-Bioenergy
, 1618
(2
), pp. 153
–162
.134.
Salbreux
, G.
, Joanny
, J. F.
, Prost
, J.
, and Pullarkat
, P.
, 2007
, “Shape Oscillations of Non-Adhering Fibroblast Cells
,” Phys. Biol.
, 4
(4
), pp. 268
–284
.135.
Qiu
, Z.
, Dubin
, A.
, Mathur
, J.
, Tu
, B.
, Reddy
, K.
, Miraglia
, L.
, Reinhardt
, J.
, Orth
, A.
, and Patapoutian
, A.
, 2014
, “SWELL1, a Plasma Membrane Protein, is an Essential Component of Volume-Regulated Anion Channel
,” Cell
, 157
(2
), pp. 447
–458
.136.
Yellin
, F.
, Li
, Y.
, Sreenivasan
, V. K. A.
, Farrell
, B.
, Johny
, M. B.
, Yue
, D.
, and Sun
, S. X.
, 2018
, “Electromechanics and Volume Dynamics in Nonexcitable Tissue Cells
,” Biophys. J.
, 114
(9
), pp. 2231
–2242
.137.
Mohagheghian
, E.
, Luo
, J.
, Chen
, J.
, Chaudhary
, G.
, Chen
, J.
, Sun
, J.
, Ewoldt
, R. H.
, and Wang
, N.
, 2018
, “Quantifying Compressive Forces Between Living Cell Layers and Within Tissues Using Elastic Round Microgels
,” Nat. Commun.
, 9
(1
), p. 1878
.138.
Han
, Y. L.
, Ronceray
, P.
, Xu
, G.
, Malandrino
, A.
, Kamm
, R. D.
, Lenz
, M.
, Broedersz
, C. P.
, and Guo
, M.
, 2018
, “Cell Contraction Induces Long-Ranged Stress Stiffening in the Extracellular Matrix
,” Proc. Natl. Acad. Sci. U. S. A.
, 115
(16
), pp. 4075
–4080
.139.
Hu
, J.
, Jafari
, S.
, Han
, Y.
, Grodzinsky
, A. J.
, Cai
, S.
, and Guo
, M.
, 2017
, “Size- and Speed-Dependent Mechanical Behavior in Living Mammalian Cytoplasm
,” Proc. Natl. Acad. Sci. U. S. A.
, 114
(36
), pp. 9529
–9534
.140.
Petrie
, R. J.
, Koo
, H.
, and Yamada
, K. M.
, 2014
, “Generation of Compartmentalized Pressure by a Nuclear Piston Governs Cell Motility in a 3D Matrix
,” Science
, 345
(6200
), pp. 1062
–1065
.141.
Rodell
, C. B.
, MacArthur
, J. W.
, Dorsey
, S. M.
, Wade
, R. J.
, Wang
, L. L.
, Woo
, Y. J.
, and Burdick
, J. A.
, 2015
, “Shear-Thinning Supramolecular Hydrogels With Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo
,” Adv. Funct. Mater.
, 25
(4
), pp. 636
–644
.142.
Babaei
, B.
, Velasquez-Mao
, A. J.
, Pryse
, K. M.
, McConnaughey
, W. B.
, Elson
, E. L.
, and Genin
, G. M.
, 2018
, “Energy Dissipation in Quasi-Linear Viscoelastic Tissues, Cells, and Extracellular Matrix
,” J. Mech. Behav. Biomed.
, 84
, pp. 198
–207
.143.
Mulhall
, H. J.
, Hughes
, M. P.
, Kazmi
, B.
, Lewis
, M. P.
, and Labeed
, F. H.
, 2013
, “Epithelial Cancer Cells Exhibit Different Electrical Properties When Cultured in 2D and 3D Environments
,” BBA-Gen. Subj.
, 1830
(11
), pp. 5136
–5141
.144.
Elson
, E. L.
, and Genin
, G. M.
, 2016
, “Tissue Constructs: Platforms for Basic Research and Drug Discovery
,” Interface Focus
, 6
(1
), p. 20150095
.145.
Mohammadalipour
, A.
, Burdick
, M. M.
, and Tees
, D. F. J.
, 2017
, “Viscoelasticity Measurements Reveal Rheological Differences Between Stem-Like and Non-Stem-Like Breast Cancer Cells
,” Cell. Mol. Bioeng.
, 10
(3
), pp. 235
–248
.146.
Babaei
, B.
, Davarian
, A.
, Lee
, S. L.
, Pryse
, K. M.
, Mcconnaughey
, W. B.
, Elson
, E. L.
, and Genin
, G. M.
, 2016
, “Remodeling by Fibroblasts Alters the Rate-Dependent Mechanical Properties of Collagen
,” Acta Biomater.
, 37
, pp. 28
–37
.147.
Bruens
, M. L.
, Pieterman
, H.
, de Wijn
, J. R.
, and Vaandrager
, J. M.
, 2003
, “Porous Polymethylmethacrylate as Bone Substitute in the Craniofacial Area
,” J. Craniofac. Surg.
, 14
(4
), pp. 596
–598
.148.
Hsu
, C. C.
, Tsai
, W. C.
, Chen
, C. P.
, Lu
, Y. M.
, and Wang
, J. S.
, 2010
, “Effects of Negative Pressures on Epithelial Tight Junctions and Migration in Wound Healing
,” Am. J. Physiol. Cell Physiol.
, 299
(2
), pp. C528
–C534
.Copyright © 2019 by ASME
You do not currently have access to this content.
