Effective delivery of the activation light for photodynamic therapy (PDT) of internal organs is a challenge. In this paper, we present a direct de-ionized water-cooling semiconductor laser package design for PDT of esophageal carcinomas. This self-sustained photonic light delivery system is designed to provide the correct amount of light dose for optimal treatment. The direct de-ionized water-cooling technique discussed in this paper not only removes heat efficiently but also results in a high optical power output. Voltage-current and power-current characteristics, and near field optical patterns for unidirectional and direct de-ionized water-cooling, are used to show the validity of the technique. Modeling of fluid flow is conducted to investigate the effect of flowing water over the laser package.

Issue Section:
Design Innovation
Keywords:
biological organs, cancer, cooling, dosimetry, flow simulation, laser applications in medicine, photodynamic therapy, semiconductor device packaging, semiconductor lasers, thermal management (packaging), tumours
Topics:
Cooling, Design, Lasers, Semiconductor lasers, Water, Photodynamic therapy, Modeling
1.
Miniño
,
A. M.
,
Heron
,
M. P.
,
Murphy
,
S. L.
, and
Kochanek
,
K. D.
, 2007, “
Deaths: Final Data for 2004
,” U.S. Department of Health and Human Services, National Vital Statistic Report.
2.
Ries
,
L. A. G.
,
Melbert
,
D.
,
Krapcho
,
M.
,
Mariotto
,
A.
,
Miller
,
B. A.
,
Feuer
,
E. J.
,
Clegg
,
L.
,
Horner
,
M. J.
,
Howlander
,
N.
,
Eisner
,
M. P.
, and
Edwards
,
B. K.
, 2007,
Seer Cancer Statistics Review, 1975–2004
,
National Cancer Institute
,
Bethesda, MD
.
3.
Blot
,
W. J.
, 2004, “
Epidemiology of Cancer
,”
Cecil Textbook of Medicine
, 22nd ed.,
L.
Goldman
 and
D.
Ausiello
, eds.,
Elsevier
,
New York
, pp.
1116
–
1119
.
4.
Chandrasoma
,
P.
, and
Taylor
,
C. R.
, 1991, “
Neoplasia:II Mechanisms and Causes of Neoplasia
,”
Concise Pathology
, 1st ed.,
Appleton & Lange
, pp.
208
–
294
.
5.
Kufe
,
D. W.
,
Pollock
,
R. E.
,
Weichselbaum
,
R. R.
,
Bast
,
R. C.
, Jr., and
Gansler
,
T. S.
, 2003,
Cancer Medicine
, 6th ed.,
BC Decker
.
6.
Bertino
,
J. R.
, and
Hait
,
W.
, 2004, “
Principles of Cancer Therapy
,”
Cecil Textbook of Medicine
, 22nd ed.,
L.
Goldman
 and
D.
Ausiello
, eds.,
Elsevier
,
New York
, pp.
1137
–
1150
.
7.
Henderson
,
B. W.
, and
Dougherty
,
T. J.
, 1992,
Photodynamic Therapy
,
Dekker
,
New York
.
8.
Orlando
,
R. C.
, 2004, “
Disease of the Esophagus
,”
Cecil Textbook of Medicine
, 22nd ed.,
L.
Goldman
 and
D.
Ausiello
, eds.,
Elsevier
,
New York
, pp.
814
–
823
.
9.
Overholt
,
B.
,
Lightdale
,
C.
,
Wang
,
K.
,
Canto
,
M.
,
Burdick
,
S.
,
Haggitt
,
R.
,
Bronner
,
M.
,
Taylor
,
S.
,
Grace
,
M.
, and
Depot
,
M.
, 2005, “
Photodynamic Therapy With Porfimer Sodium for Ablation of High-Grade Dysplasia in Barrett’s Esophagus: International, Partially Blinded, Randomized Phase III Trial
,”
Gastrointest. Endosc.
,
62
(
4
), pp.
488
–
498
. 0016-5107
Crossref
Search ADS
PubMed
 
10.
Panjehpour
,
M.
,
Overholt
,
B. F.
, and
Haydek
,
J. M.
, 2000, “
Light Sources and Delivery Devices for Photodynamic Therapy in the Gastrointestinal Tract
,”
Gastrointest Endosc Clin. N. Am.
,
10
(
3
), pp.
513
–
532
. 1052-5157
Crossref
Search ADS
PubMed
 
11.
Charamisinau
,
I.
,
Happawana
,
G. S.
,
Evans
,
G.
,
Kirk
,
J. B.
,
Bour
,
D. P.
,
Rosen
,
A.
, and
His
,
R. A.
, 2005, “
High-Power Semiconductor Red Laser Arrays for Use in Photodynamic Therapy
,”
IEEE J. Sel. Top. Quantum Electron.
1077-260X,
11
(
4
), pp.
881
–
891
.
Crossref
Search ADS
 
12.
Charamisinau
,
I.
,
Happawana
,
G.
,
Evans
,
G.
,
Rosen
,
A.
,
His
,
R. A.
, and
Bour
,
D.
, 2005, “
Semiconductor Laser Insert With Uniform Illumination for Use in Photodynamic Therapy
,”
Appl. Opt.
0003-6935,
44
(
24
), pp.
5055
–
5068
.
Crossref
Search ADS
PubMed
 
13.
Charamisinau
,
I.
,
Happawana
,
G.
,
Evans
,
G.
,
Rosen
,
A.
, and
His
,
R. A.
, 2003, “
Portable Optical Actuator for Photodynamic Therapy
,”
Proc. SPIE
0277-786X,
5261
, pp.
38
–
46
.
14.
Rosen
,
A.
, and
Rosen
,
H.
, 1991, “
Catheter With Distally Located Integrated Circuit Radiation Generator
,” U.S. Patent No. 4998932.
15.
Bacon
,
D. D.
,
Katz
,
A.
,
Lee
,
C. H.
,
Tai
,
K. I.
, and
Wong
,
Y. M.
, 1994, “
Permanent Metallic Bonding Method
,” U.S. Patent No. 5234153.
16.
Xu
,
T.
,
Li
,
Y.
, and
Wu
,
X.
, 2005, “
Application of Lower Fluence Rate for Less Microvasculature Damage and Greater Cell-Killing During Photodynamic Therapy
,”
Lasers Med. Sci.
,
19
(
4
), pp.
257
–
261
. 0268-8921
Crossref
Search ADS
PubMed
 
17.
Pogue
,
B. W.
,
Lilge
,
L.
,
Patterson
,
M. S.
,
Wilson
,
B. C.
, and
Hasan
,
T.
, 1997, “
Absorbed Photodynamic Dose From Pulsed Versus Continuous Wave Light Examined With Tissue-Simulating Dosimeters
,”
Appl. Opt.
,
36
, pp.
7257
–
7269
. 0003-6935
Crossref
Search ADS
PubMed
 
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