This study was motivated by a goal to understand the mixing and emissions in the rich-burn/quick-mix/lean-burn combustor scheme that has been proposed to minimize the formation of oxides of nitrogen in gas turbine combustors. The study reported in this paper was a reacting jet-in-crossflow experiment at atmospheric pressure in a cylindrical duct. The jets were injected from the perimeter of the duct through round-hole orifices into a fuel-rich mainstream flow. The number of orifices investigated in this study gave over- to optimum to underpenetrating jets at a jet-to-mainstream momentum-flux ratio of 57. The size of individual orifices was decreased as their number increased to maintain a constant total area. The jet-to-mainstream mass-flow ratio was held constant at 2.5. The experiments focused on the effects of the number of orifices and inlet air preheat and were conducted in a facility that provided the capability for independent variation of jet and main inlet air preheat temperature. The number of orifices was found to have a significant effect on mixing and the distributions of species, but very little effect on overall emissions, suggesting that an aerodynamically optimum mixer may not minimize emissions. Air preheat was found to have very little effect on mixing and the distributions of major species, but preheat did increase emissions significantly. Although the air jets injected in the quick-mix section of a RQL combustor may comprise over 70% of the total air flow, the overall emission levels were found to be more sensitive to mainstream air preheat than to jet stream air preheat.