This paper is carried out on the computer simulation of breast cancer treated using a high intensity focused ultrasound (HIFU). The mathematical models consist of the pressure acoustics equation, bioheat equation, heat transfer in a blood vessel, momentum equations in a blood vessel, and mechanical deformation equation. In the numerical simulation, these mathematical models are solved by using an axisymmetric finite element method (FEM) with time-dependent, thermal and acoustic properties to describe the temperature distribution and the total displacement in tissue. The comparison of the simulated results in the model with two sizes of the cancer tumor and two frequencies of ultrasound are also considered in order to approach realistic tissue modeling. The results show that the breast cancer model with deformation, which is the more accurate way to simulate the physical characteristics of therapeutic breast cancer compared to the literature results, hence leads to more useful in the medical approach and this study was conducted to prevent errors caused by inaccurate focal points.