Experimental intranasal (IN) delivery of nanoparticle (NP) drug carriers is typically performed using a pipette with or without anesthesia, a technique that may be a poor simulation of practical IN administration of drug-loaded NPs in humans. Existing IN spray devices suffer from drawbacks in terms of variability in dose-control and spray duration as well as the application of nonuniform pressure fields when a NP-formulated drug is aerosolized. Furthermore, existing spray devices require large volumes that may not be available or may be prohibitively expensive to prepare. In response, we have developed a novel pneumatically driven IN spray device for the administration of NPs, which is capable of administering extremely small quantities (50–100 μl) of NP suspension in a fine spray that disperses the NPs uniformly onto the tissue. This device was validated using haloperidol-loaded Solanum tuberosum lectin (STL)-functionalized, poly(ethylene glycol)–block-poly(d,l-lactic-co-glycolic acid) (PEG–PLGA) NPs targeted for delivery to the brain for schizophrenia treatment. A pneumatic pressure of 100 kPa was found to be optimal to produce a spray that effectively aerosolizes NP suspensions and delivers them evenly to the olfactory epithelium. IN administration of STL-functionalized NPs using the IN spray device increased brain tissue haloperidol concentrations by a factor of 1.2–1.5× compared to STL-functionalized NPs administered IN with a pipette. Such improved delivery enables the use of lower drug doses and thus offers both fewer local side-effects and lower costs without compromising therapeutic efficacy.
A Novel Intranasal Spray Device for the Administration of Nanoparticles to Rodents
Manuscript received August 13, 2014; final manuscript received February 11, 2015; published online August 6, 2015. Assoc. Editor: Rupak K. Banerjee.
- Views Icon Views
- Share Icon Share
- Search Site
Piazza, J. E., Zhu, C., Ravi Selvaganapathy, P., R. Hoare, T., Jain, S. B., Hossain, F., and Mishra, R. K. (August 6, 2015). "A Novel Intranasal Spray Device for the Administration of Nanoparticles to Rodents." ASME. J. Med. Devices. December 2015; 9(4): 041001. https://doi.org/10.1115/1.4029907
Download citation file: