In gas turbine, multi-stage row blading and technological effects can exhibit significant differences for the flow compared with isolated smooth blade rows. Upstream stages promote a non-uniform flow field at the inlet of the downstream rows that may have large effects on mixing or boundary layer transition processes. The rows of current turbines (and compressors) are already very closely spaced. Axial gaps between adjacent rows of approximately 1/4 to 1/2 of the axial blade chord are common practice. Future designs with higher loading and lower aspect ratios, i.e., fewer and bigger blades, and the ever present aim at minimizing engine length or compactness, will aggravate this condition even further. Interaction between cascade rows will therefore keep increasing and need to be taken into account in loss generation estimation. Also the cavities at hub platform induce purge flow blowing into main annulus and additional losses for the turbine. A robust method to account for the loss generated due to these different phenomena needs to be used. The notion of exergy (energy in the purpose to generate work) provides a general framework to deal with the different transfers of energy between the flow and the gas turbine. This study investigates the flow in a two-stage configuration representative of a low-pressure turbine including hub cavities based on large eddy simulation (LES). A description of the flow in the cavities, the main annulus, and at rim seal interface is proposed. The assessment of loss generated in the configuration is proposed based on an exergy analysis. The study of losses restricted to boundary layer contributions and secondary flows show the interaction processes of secondary vortices and wake generated in upstream rows on the flow in downstream rows.