This article describes the transport and the interaction of pulsating entropy waves generated by combustor burners within a high-pressure turbine stage for aeronautical application. Experiments and computational fluid dynamics (CFD) simulations were carried out in the context of the European Research Project RECORD. Experimental campaigns considering burner-representative temperature fluctuations (in terms of spot shape, fluctuation frequency, and total temperature variation percentage) injected upstream of an un-cooled high-pressure gas turbine stage have been performed in the high-speed closed-loop test rig of the Fluid Machine Laboratory (LFM) of the Politecnico di Milano (Italy). The pulsating entropy waves are injected at the stage inlet in streamwise direction at four different azimuthal positions featuring a 7% overtemperature with respect to the main flow with a frequency of 90 Hz. Detailed time-resolved temperature measurements (in the range of 0–200 Hz) upstream and downstream of the stage, as well as in the stator–rotor axial gap, were performed. Time-accurate CFD simulations with and without entropy fluctuations imposed at the stage inlet were performed with the TRAF code, developed by the Università degli Studi di Firenze (Italy). A numerical postprocessing procedure, based on the discrete Fourier transform (DFT) of the conservative variables, has been implemented to extract the low-frequency content connected to the entropy fluctuations. Measurements highlighted a significant attenuation of the entropy wave spot throughout their transport within the stator channel and their interaction with the rotor blade rows, highly depending on their injection azimuthal position. Simulations show an overall good agreement with the experiments on the measurement traverses, especially at the stage outlet. By exploiting the combination of experiments and simulations, the aerodynamic and thermal implications of the temperature fluctuation injected upstream of the stage were properly assessed, thus allowing suggest useful information to the designer. The comparison with the experiments confirms the accuracy of the CFD method to solve the periodic, but characterized by a low-frequency content event, associated with the entropy wave fluctuation.