The current trend in turbomachinery toward broader operating characteristics requires that operating points in the off-design region can be captured accordingly from the simulation models. Complex processes like separation and vortex formation/dissipation occur under these conditions. Linear two equation models are often not able to represent these effects correctly since their derivation is based on oversimplifications, such as the Boussinesq hypothesis, which makes it impossible to capture anisotropic turbulence. Advanced RANS models are usually not considered in the design process of turbomachines because (1) they are usually more delicate with regards to stability and convergence behavior and (2) require additional computational effort. To make the usage of advanced RANS models more applicable for complex turbomachinery simulations, a selected group of models were implemented into a robust framework of a pressure-based fully coupled solver. To further enhance stability, coupling terms between the turbulent transport equations were derived for several models. Anisotropic turbulence is introduced by computing an algebraic expression or by solving the transport equations for the Reynolds stress components. The evaluation of the models is performed on the RWTH Aachen “Radiver” centrifugal compressor case with vaned diffuser. For design conditions and operation points near the stability limit, all investigated turbulence models predict the compressor characteristic. Operation points in the choking region, on the other hand, are only predicted well by anisotropic models. The good results and improved convergence behavior of the advanced RANS models clearly indicates their applicability in the design process of turbomachines.