The coupling of aerodynamics and structural mechanics is an important step in the design process of aeronautical devices with morphing parts. In this article, a 2D–3D coupling approach is developed to study a morphing blade cascade. Two shape memory alloy actuators are placed on the upper and lower sides of the blade to make possible the change in shape of the leading edge. In the present study, a preliminary design study is conducted by considering a two-dimensional computational fluid dynamics (CFD) analysis of an airfoil cascade coupled with a three-dimensional structural analysis of the whole 3D blade. A methodology is developed to match 2D and 3D meshes such that the aerodynamic loads can be easily transferred to the structural analysis. From there, the deformed blade geometry due to both aerodynamic loads and actuator work can be transferred back to the CFD solver, and the iterative aero-structural coupling loop can be repeated until convergence. The aero-structural coupling strategy developed in this study is also applied to a blade cascade study aiming to improve its performance by morphing the leading-edge of the blade. The results of this application show that by morphing the leading-edge blade of only few millimeters (less than 2 mm), it is possible to achieve a relevant performance improvement in terms of total pressure loss coefficient decrease of about 53% considering off-design conditions.